Mkhize said the roll-out will be put on hold until a committee of scientists have decided the way forward.
The government had intended to roll the AstraZeneca shot out to healthcare workers soon, after receiving 1 million doses produced by the Serum Institute of India on Monday.
Instead, it will offer vaccines developed by Johnson & Johnson and Pfizer in the coming weeks while experts consider how the AstraZeneca shot can be deployed.
“What does that mean for our vaccination programme which we said will start in February? The answer is it will proceed,” Mkhize told an online news briefing.
“From next week for the next four weeks we expect that there will be J&J vaccines, there will be Pfizer vaccines. So what will be available to the health workers will be those vaccines.”
“The AstraZeneca vaccine will remain with us … up until the scientists give us clear indications as to what we need to do,” he added.
Wits Professor Shabir Madhi told a media briefing on Sunday that results from the trials show that the AstraZeneca vaccine was less effective against mild and moderate forms of the B.1.351 coronavirus variant first identified in the country. He said it was “disappointing” and a reality check.
Madhi said the recruitment of the over 2000 participants started towards the end of the first wave, but while the study was under way the new variant started spreading in the country -especially in the Eastern Cape and became a dominant part of the second wave of the pandemic.
Madhi said evidence collected showed that the AstraZeneca vaccine was less effective against the new variant. Before October 31, when the trial began – results showed promise and the likelihood of protecting against mild cases of the virus. Results had shown that the vaccine was 75% effective with a single dose in 14 days. These same results could not be replicated based on the new variant.
He said the question of whether the AstraZeneca vaccine would be effective against severe forms of the virus had not been answered as the study did not aim to answer that question. A larger study would be needed, Mahdi said.
He said had the virus not mutated, the results would have been promising.
Madhi said it was not all “doom and gloom” as vaccines like the one-dose vaccine offered by Johnson & Johnson offered more promising effectiveness against the SA variant and severe forms of the virus.
Professor Glenda Gray agreed that early results from the Johnson & Johnson vaccine were more promising and the vaccine could be a “silver bullet”.
The single-dose vaccine was shown to be 85 percent effective in preventing severe disease and death in the 501Y.V2 variant.
“We are in advanced discussions to further evaluate the single shot Covid vaccine in South Africa in an accelerated manner,” said Gray.
Mkhize told members of the health portfolio committee on Friday that the country would also get 9 million doses from Johnson & Johnson, 20 million from Pfizer and 12 million from the Covax facility.